{"product_id":"matrixyl","title":"Matrixyl","description":"\u003ch3\u003eMatrixyl (Palmitoyl Pentapeptide-4 \/ Pal-KTTKS)\u003c\/h3\u003e\n\u003ch3\u003e1. Basic Overview\u003c\/h3\u003e\n\u003cp\u003e\u003cspan\u003eMatrixyl, chemical name \u003c\/span\u003e\u003cstrong\u003ePalmitoyl Pentapeptide-4 (Pal-KTTKS)\u003c\/strong\u003e\u003cspan\u003e, is a synthetic lipophilic signal peptide developed by Sederma.\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eAmino Acid Sequence: Palmitoyl-Lys-Thr-Thr-Lys-Ser\u003c\/li\u003e\n\u003cli\u003eCAS Number: 214047-00-4\u003c\/li\u003e\n\u003cli\u003eMolecular Weight: 802.05 Da\u003c\/li\u003e\n\u003cli\u003eForm: Lyophilized white crystalline powder\u003c\/li\u003e\n\u003cli\u003eCore feature: The palmitoyl fatty acid chain improves skin penetration. It acts as a matrikine to stimulate fibroblasts to rebuild dermal extracellular matrix.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cdiv\u003eClarification:\n\u003cul\u003e\n\u003cli\u003eOriginal Matrixyl = Palmitoyl Pentapeptide-4\u003c\/li\u003e\n\u003cli\u003eMatrixyl 3000 = Blend: Palmitoyl Tripeptide-1 + Palmitoyl Tetrapeptide-7\u003c\/li\u003e\n\u003cli\u003eMatrixyl Synthe’6 = Palmitoyl Tripeptide-38 (separate multi-matrix stimulator)\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003ch3\u003e2. Mechanism of Action\u003c\/h3\u003e\n\u003col\u003e\n\u003cli\u003eMimics natural collagen breakdown fragments (matrikine signaling). It signals dermal fibroblasts to initiate tissue remodeling response.\u003c\/li\u003e\n\u003cli\u003eUpregulates TGF-β pathway, significantly boosting synthesis of Collagen I, III, IV, fibronectin and glycosaminoglycans.\u003c\/li\u003e\n\u003cli\u003eBalances matrix metalloproteinase (MMP) activity to slow excessive collagen degradation.\u003c\/li\u003e\n\u003cli\u003eEnhances epidermal-dermal junction integrity, improves skin thickness and reduces fine wrinkle formation.\u003c\/li\u003e\n\u003cli\u003eSupports angiogenesis and accelerates mild wound healing in epithelial tissue models.\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003ch3\u003e3. Main Research Applications\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eSkin aging, wrinkle formation and dermal thinning research\u003c\/li\u003e\n\u003cli\u003eFibroblast extracellular matrix synthesis in vitro experiments\u003c\/li\u003e\n\u003cli\u003eTopical peptide penetration \u0026amp; lipopeptide delivery system studies\u003c\/li\u003e\n\u003cli\u003eSkin barrier repair and anti-photoaging models\u003c\/li\u003e\n\u003cli\u003eComparative research: Matrixyl vs GHK-Cu, Argireline, and other cosmetic peptides\u003c\/li\u003e\n\u003cli\u003eFormulation development for anti-aging serum \u0026amp; cream prototypes\u003c\/li\u003e\n\u003cli\u003eCombined peptide research with hyaluronic acid, vitamin C and retinoids\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e4. Reconstitution Instructions (Lyophilized Vial)\u003c\/h3\u003e\n\u003cp\u003e\u003cspan\u003eCommon specification: \u003c\/span\u003e\u003cstrong\u003e5mg \/ 10mg per vial\u003c\/strong\u003e\u003cspan\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003col\u003e\n\u003cli\u003eAllow vial to reach room temperature; disinfect rubber stopper with alcohol wipe.\u003c\/li\u003e\n\u003cli\u003eSlowly inject Bacteriostatic Water along the inner glass wall. Avoid direct impact onto lyophilized powder.\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cdiv\u003eStandard mixing scheme: 10mg powder + 2mL BAC water → Concentration = 5 mg\/mL\u003c\/div\u003e\n\u003col start=\"3\"\u003e\n\u003cli\u003eGently rotate the vial to dissolve powder.\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003eDO NOT shake violently to prevent peptide aggregation.\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eQualified solution is clear and colourless.\u003c\/li\u003e\n\u003cli\u003eStorage Requirements\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cul\u003e\n\u003cli\u003eUnreconstituted lyophilized powder: Hermetically sealed, stored at -20°C, protected from light. Stable for up to 24 months.\u003c\/li\u003e\n\u003cli\u003eReconstituted peptide solution: Refrigerate 2°C ~ 8°C, stable within 28 days.\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003eDo not freeze reconstituted liquid.\u003c\/strong\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e5. Research Administration Protocols\u003c\/h3\u003e\n\u003cdiv\u003ePrimary research route: Topical application (standard). Subcutaneous injection is rare and experimental only.\u003c\/div\u003e\n\u003ch3\u003eTopical Application (Main Experimental Method)\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eWorking concentration for in vivo skin research:\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003e0.5mg\/mL – 2.5mg\/mL\u003c\/strong\u003e\n\u003c\/li\u003e\n\u003cli\u003eApplication frequency: Once or twice daily\u003c\/li\u003e\n\u003cli\u003eOperation: Apply evenly to target skin region; gently massage for absorption. Allow full penetration before overlaying other agents.\u003c\/li\u003e\n\u003cli\u003eReference experimental cycle: Continuous treatment for 8–12 weeks to observe ECM remodeling changes.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSubcutaneous Injection (Only for specialized animal research)\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eReference experimental dosage:\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003e200–500 mcg, once daily\u003c\/strong\u003e\n\u003c\/li\u003e\n\u003cli\u003eInjection site: Localized subcutaneous tissue near experimental skin lesion\u003c\/li\u003e\n\u003cli\u003eCycle: Max 6 weeks continuous administration; pause 4 weeks before new research cycle.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e6. Precautions \u0026amp; Observed Adverse Reactions\u003c\/h3\u003e\n\u003col\u003e\n\u003cli\u003ePure laboratory research compound. Not authorized for human therapeutic injection.\u003c\/li\u003e\n\u003cli\u003eStrict aseptic technique required during reconstitution to prevent microbial contamination.\u003c\/li\u003e\n\u003cli\u003eDiscard solution immediately if turbidity, precipitation or discoloration appears.\u003c\/li\u003e\n\u003cli\u003eObserved mild reactions: occasional transient local redness or slight irritation in sensitive tissue models. Systemic side effects are extremely rare.\u003c\/li\u003e\n\u003cli\u003eMatrixyl is lipophilic; avoid mixing with strongly acidic or alkaline solutions to prevent structural degradation.\u003c\/li\u003e\n\u003cli\u003eNot interchangeable with Matrixyl 3000 or Synthe’6; peptide composition and activity spectrum differ.\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003chr\u003e\n\u003ch3\u003eShort Version (For Product Page \/ Customer Direct Message)\u003c\/h3\u003e\n\u003ch3\u003eMatrixyl (Palmitoyl Pentapeptide-4 \/ Pal-KTTKS)\u003c\/h3\u003e\n\u003cp\u003e\u003cspan\u003eMatrixyl is a lipophilic synthetic signal peptide (matrikine). It stimulates dermal fibroblasts to produce collagen, fibronectin and other extracellular matrix components. Widely used in laboratory research focusing on skin anti-aging, wrinkle improvement, epidermal repair and cosmetic peptide formulation testing.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3\u003eReconstitution\u003c\/h3\u003e\n\u003cp\u003e\u003cspan\u003eMix lyophilized powder with bacteriostatic water. Rotate gently; avoid violent shaking. Reconstituted solution must be refrigerated and used within 28 days.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3\u003eReference Research Administration\u003c\/h3\u003e\n\u003cp\u003e\u003cspan\u003eTopical: 0.5–2.5 mg\/mL solution, 1–2 times daily for 8–12 weeks. Subcutaneous injection (animal research only): 200–500 mcg once daily.\u003c\/span\u003e\u003c\/p\u003e","brand":"我的商店","offers":[{"title":"10mg*10vials","offer_id":53703732330796,"sku":null,"price":26.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0979\/1406\/1100\/files\/b5c20b62e803e3f2f2afb58187d52b22ac26904d0d179de45ed883bafcff0f03_1.png?v=1786601694","url":"https:\/\/0rw2.com\/products\/matrixyl","provider":"0rw2.com","version":"1.0","type":"link"}