{"product_id":"bronchogen","title":"bronchogen","description":"\u003ch3\u003eBronchogen (AEDL) Peptide\u003c\/h3\u003e\n\u003ch3\u003e1. Basic Profile\u003c\/h3\u003e\n\u003cp\u003e\u003cspan\u003eBronchogen, also known as \u003c\/span\u003e\u003cstrong\u003eAEDL (H-Ala-Glu-Asp-Leu-OH)\u003c\/strong\u003e\u003cspan\u003e, is a synthetic short tetrapeptide bioregulator developed by Professor Vladimir Khavinson’s research group. It belongs to the organ-specific peptide bioregulator series, engineered to target bronchial and pulmonary epithelial tissue.\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eAmino Acid Sequence: L-Alanyl-L-Glutamyl-L-Aspartyl-L-Leucine (AEDL)\u003c\/li\u003e\n\u003cli\u003eMolecular Weight: 446.44 Da\u003c\/li\u003e\n\u003cli\u003eForm: Lyophilized white powder\u003c\/li\u003e\n\u003cli\u003eHalf-life: Very short (minutes in circulation); long-lasting epigenetic effects persist after peptide clearance\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e2. Mechanism of Action\u003c\/h3\u003e\n\u003cp\u003e\u003cspan\u003eBronchogen differs from conventional receptor-binding peptides. It penetrates cell membranes and enters the cell nucleus to interact with DNA, modulating gene expression of respiratory tissue cells.\u003c\/span\u003e\u003c\/p\u003e\n\u003col\u003e\n\u003cli\u003eUpregulate lung-specific transcription factors (NKX2-1, FOXA1, FOXA2, SCGB1A1) to maintain normal differentiation of bronchial epithelial cells.\u003c\/li\u003e\n\u003cli\u003eProtect ciliated epithelial cells, improve mucociliary clearance function of the airway.\u003c\/li\u003e\n\u003cli\u003eBalance inflammatory cytokines (TNF-α, IL-6), reduce chronic low-grade inflammation in respiratory tract.\u003c\/li\u003e\n\u003cli\u003ePromote repair of damaged bronchial mucosal barrier; support regeneration of airway epithelium.\u003c\/li\u003e\n\u003cli\u003eBoost pulmonary surfactant synthesis to stabilize alveolar structure and improve gas exchange efficiency.\u003c\/li\u003e\n\u003cli\u003eResearch target: age-related lung function decline, post-infection respiratory tissue recovery, and chronic airway injury models.\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003ch3\u003e3. Main Observed Research Effects\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eRestore integrity of bronchial epithelial lining\u003c\/li\u003e\n\u003cli\u003eReduce airway inflammation and mucosal irritation\u003c\/li\u003e\n\u003cli\u003eImprove respiratory tissue repair after viral or bacterial respiratory infections\u003c\/li\u003e\n\u003cli\u003eSlow age-related degeneration of lung tissue\u003c\/li\u003e\n\u003cli\u003eSupport normal mucus clearance and reduce mucus overproduction\u003c\/li\u003e\n\u003cli\u003eEnhance local respiratory mucosal immune defense\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e4. Reconstitution Instructions (Lyophilized Vial)\u003c\/h3\u003e\n\u003cp\u003e\u003cspan\u003eCommon specifications: \u003c\/span\u003e\u003cstrong\u003e10mg \/ 20mg per vial\u003c\/strong\u003e\u003cspan\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003col\u003e\n\u003cli\u003eAllow the peptide vial to reach room temperature; disinfect the rubber stopper with alcohol.\u003c\/li\u003e\n\u003cli\u003eSlowly inject Bacteriostatic Water (BAC water) along the inner wall of the vial, avoid direct impact onto powder.\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cdiv\u003eRecommended mixing scheme: 10mg powder + 2mL BAC water → Concentration = 5 mg\/mL\u003c\/div\u003e\n\u003col start=\"3\"\u003e\n\u003cli\u003eGently rotate the vial to dissolve powder.\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003eDO NOT shake violently to prevent peptide degradation and foaming.\u003c\/strong\u003e\n\u003c\/li\u003e\n\u003cli\u003eStorage Requirements\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cul\u003e\n\u003cli\u003eUnreconstituted lyophilized powder: Store sealed at -20°C, protected from light. Shelf life up to 24 months.\u003c\/li\u003e\n\u003cli\u003eReconstituted peptide solution: Refrigerate at 2°C ~ 8°C, stable within 28 days. Avoid repeated freeze-thaw cycles.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e5. Research Administration Protocols\u003c\/h3\u003e\n\u003ch3\u003eOption 1: Subcutaneous Injection (Most Common Lab Protocol)\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eStarting dosage:\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003e500 mcg daily\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003e(adaptation phase)\u003c\/li\u003e\n\u003cli\u003eStandard maintenance dosage:\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003e750 mcg – 1000 mcg daily\u003c\/strong\u003e\n\u003c\/li\u003e\n\u003cli\u003eTiming: Administer in the evening, 1–2 hours after meals\u003c\/li\u003e\n\u003cli\u003eInjection site: Lower abdomen subcutaneous tissue; rotate injection points regularly\u003c\/li\u003e\n\u003cli\u003eCycle Schedule: 4 weeks on cycle → 8 weeks off cycle; repeat cycles for long-term observation\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eOption 2: Inhalation \/ Intranasal Administration (Respiratory Direct Delivery Research)\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eReference working concentration: 0.25 mg\/mL ~ 1 mg\/mL\u003c\/li\u003e\n\u003cli\u003eOnce daily delivery for localized airway experimental research\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cdiv\u003eNote: Oral protocols exist in Russian preclinical literature but are less widely adopted in international peptide laboratory research.\u003c\/div\u003e\n\u003ch3\u003e6. Precautions\u003c\/h3\u003e\n\u003col\u003e\n\u003cli\u003ePure laboratory research reagent. Not approved for human medical use.\u003c\/li\u003e\n\u003cli\u003eStrict sterile operation required during reconstitution to avoid bacterial contamination.\u003c\/li\u003e\n\u003cli\u003eIf turbidity, precipitation or abnormal local irritation occurs, terminate the experiment immediately.\u003c\/li\u003e\n\u003cli\u003eLimited independent large-scale human clinical data; all effects are concluded from preclinical and in-vitro cell studies.\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003chr\u003e\n\u003ch3\u003eShort Version (For Product Page \/ WhatsApp \/ Customer Message)\u003c\/h3\u003e\n\u003ch3\u003eBronchogen (AEDL) Peptide\u003c\/h3\u003e\n\u003cp\u003e\u003cspan\u003eBronchogen (AEDL) is a Khavinson-series tetrapeptide bioregulator targeting bronchopulmonary tissue. It enters cell nuclei to regulate gene expression of airway epithelial cells, study mucosal repair, airway inflammation relief, and lung tissue anti-aging.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3\u003eReconstitution\u003c\/h3\u003e\n\u003cp\u003e\u003cspan\u003eDissolve lyophilized powder with bacteriostatic water. Rotate gently to dissolve without shaking.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3\u003eReference Subcutaneous Research Dosage\u003c\/h3\u003e\n\u003cp\u003e\u003cspan\u003eStart at 500 mcg daily; standard dose 750–1000 mcg daily. Cycle: 4 weeks on, then 8 weeks break.\u003c\/span\u003e\u003c\/p\u003e","brand":"我的商店","offers":[{"title":"20mg*10vials","offer_id":53703822737708,"sku":null,"price":72.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0979\/1406\/1100\/files\/81b49e6f422435e6fdc7c7807f7889fc473e9b6fb20b77ea7355f7a0f16a4e2a.png?v=1786604884","url":"https:\/\/0rw2.com\/products\/bronchogen","provider":"0rw2.com","version":"1.0","type":"link"}