AHK-CU

AHK-Cu (Alanyl-Histidyl-Lysine Copper Complex)

Full Introduction & Administration Guide IMPORTANT DISCLAIMER: For laboratory research use only. Not for human consumption, clinical treatment, injection or cosmetic application. All data is for experimental reference merely.

1. Basic Overview

AHK-Cu, also known as Copper Tripeptide-3, is a synthetic tripeptide copper complex with amino acid sequence Ala-His-Lys chelated with copper(II) ion. It is a structural analog of the well-known GHK-Cu. Alanine replaces glycine at the N-terminal position, which alters lipophilicity and cellular binding affinity. In vitro research shows AHK-Cu exhibits stronger selectivity toward dermal papilla cells, making it widely studied in hair regeneration, skin remodeling and wound healing research. Molecular Formula: C₁₄H₂₂CuN₆O₄ CAS: 767286-83-9

2. Mechanism of Action

1. Stimulate proliferation of dermal papilla cells (DPCs), inhibit DPC apoptosis, extend hair follicle anagen (growth) phase.
2. Upregulate VEGF and SCF expression, boost microvascular angiogenesis around follicles to improve nutrient supply.
3. Promote fibroblast activity and Type I collagen synthesis, support dermis reconstruction and anti-fibrosis research.
4. Deliver bioavailable copper ions as essential enzyme cofactor; moderate oxidative stress and relieve local inflammation.
5. Activate Wnt/β-catenin signaling pathway critical for follicle regeneration.

3. Primary Observed Research Effects

• Activate dormant hair follicles, counteract follicle miniaturization
• Improve hair density and hair shaft thickness in preclinical models
• Accelerate skin tissue repair and wound closure
• Boost collagen synthesis, investigate anti-aging skin remodeling
• Reduce inflammatory response in epidermal tissue models

4. Reconstitution Instructions (Lyophilized Powder)

Standard specification: 5mg / 10mg per vial

1. Let the peptide vial warm to room temperature first. Sterilize rubber stopper with alcohol wipe.
2. Slowly inject Bacteriostatic Water (BAC water) along the inner wall of the vial, avoid direct impact on lyophilized powder.

3. Gently swirl/roll the vial to dissolve powder. DO NOT shake violently to prevent peptide denaturation. Fully dissolved solution displays characteristic light blue color.
4. Storage Rules

• Unreconstituted lyophilized powder: Store at -20°C, sealed and protected from light. Shelf life up to 24 months.
• Reconstituted solution: Refrigerate 2–8°C, stable within 28 days. Avoid repeated freeze-thaw cycles and light exposure.

5. Research Administration Protocols

Option 1: Subcutaneous Injection (Localized Research)

• Reference Dosage: 100 mcg – 300 mcg per injection
• Frequency: 3–5 times weekly
• Injection Site: Abdominal subcutaneous tissue or target scalp region
• Cycle Reference: 8–12 weeks experimental cycle, followed by equal rest period

Option 2: Topical Application (Dermatology & Hair Research)

• Working concentration range: 0.1 mg/mL ~ 2 mg/mL
• Application: Apply evenly to target tissue area, once or twice daily for experimental observation

6. Precautions

1. Purely laboratory research reagent. Not approved for human medical use.
2. Copper peptide is sensitive to oxidation. Avoid long-term exposure under light.
3. Strict sterile operation required during reconstitution to prevent contamination.
4. Cease experiment immediately if precipitation, turbidity or abnormal irritation occurs.

Short Version (For Product Page / Customer Direct Message)

AHK-Cu Peptide

AHK-Cu (Copper Tripeptide-3) is a synthetic copper tripeptide complex, structural analog of GHK-Cu. It targets dermal papilla cells to study hair follicle regeneration, angiogenesis, collagen synthesis and skin tissue repair.

Reconstitution

Dissolve lyophilized powder with bacteriostatic water. Gently swirl to dissolve. The finished solution appears pale blue.

Reference Research Dosage (Subcutaneous)

100–300 mcg per injection, 3–5 times weekly. Cycle: 8–12 weeks.