{"product_id":"ace-031","title":"ACE-031","description":"\u003ch3\u003eProduct Overview\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eFull Name: ACE-031, INN: Ramatercept\u003c\/li\u003e\n\u003cli\u003eSynonyms: Soluble Activin Receptor Type IIB-Fc, Myostatin Ligand Trap\u003c\/li\u003e\n\u003cli\u003eClassification: Recombinant dimeric Fc-fusion protein (not a short synthetic peptide)\u003c\/li\u003e\n\u003cli\u003eCAS Number: 1169766-01-1\u003c\/li\u003e\n\u003cli\u003eMolecular Weight: ~90–95 kDa\u003c\/li\u003e\n\u003cli\u003eStructural Composition: Extracellular ligand-binding domain of human ActRIIB fused to the Fc constant region of human IgG1\u003c\/li\u003e\n\u003cli\u003eCore Mechanism: Broad-spectrum TGF-β superfamily decoy receptor\n\u003col\u003e\n\u003cli\u003eHigh-affinity sequestration of myostatin (GDF-8), activin A\/B, GDF-11 and select BMPs\u003c\/li\u003e\n\u003cli\u003eBlocks ligand binding to native membrane ActRIIA\/ActRIIB receptors on muscle satellite cells and mature myofibers\u003c\/li\u003e\n\u003cli\u003eSuppresses downstream Smad2\/3 inhibitory signaling, unlocks mTOR\/Akt anabolic pathways\u003c\/li\u003e\n\u003cli\u003eIgG1-Fc domain extends plasma half-life to 10–15 days via FcRn recycling for long-lasting single-dose efficacy\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003c\/li\u003e\n\u003cli\u003ePurity: ≥99% verified via ; Endotoxin \u0026lt; 1 EU\/mg, full COA batch testing provided\u003c\/li\u003e\n\u003cli\u003eIntended Use: Laboratory research only (RUO – Research Use Only); Phase 2 human clinical trials discontinued due to vascular safety signals\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eProduct Attributes\u003c\/h3\u003e","brand":"我的商店","offers":[{"title":"1mg*10vials","offer_id":53703695270188,"sku":null,"price":31.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0979\/1406\/1100\/files\/f9451a5e9e5573b682ed26869cd439b77a64963bd6dd935386a2c59207b8de5d.png?v=1786599730","url":"https:\/\/0rw2.com\/products\/ace-031","provider":"0rw2.com","version":"1.0","type":"link"}