ACE-031

Product Overview

• Full Name: ACE-031, INN: Ramatercept
• Synonyms: Soluble Activin Receptor Type IIB-Fc, Myostatin Ligand Trap
• Classification: Recombinant dimeric Fc-fusion protein (not a short synthetic peptide)
• CAS Number: 1169766-01-1
• Molecular Weight: ~90–95 kDa
• Structural Composition: Extracellular ligand-binding domain of human ActRIIB fused to the Fc constant region of human IgG1
• Core Mechanism: Broad-spectrum TGF-β superfamily decoy receptor
  1. High-affinity sequestration of myostatin (GDF-8), activin A/B, GDF-11 and select BMPs
  2. Blocks ligand binding to native membrane ActRIIA/ActRIIB receptors on muscle satellite cells and mature myofibers
  3. Suppresses downstream Smad2/3 inhibitory signaling, unlocks mTOR/Akt anabolic pathways
  4. IgG1-Fc domain extends plasma half-life to 10–15 days via FcRn recycling for long-lasting single-dose efficacy
• Purity: ≥99% verified via ; Endotoxin < 1 EU/mg, full COA batch testing provided
• Intended Use: Laboratory research only (RUO – Research Use Only); Phase 2 human clinical trials discontinued due to vascular safety signals

Product Attributes